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LaPlace is a census-designated place (CDP) in St. John the Baptist Parish, Louisiana, situated on the east bank of the Mississippi River in the New Orleans metropolitan area.

Present-day LaPlace was settled by German immigrants in the early 18th century as Karlstein, one of the four settlements of the German Coast, and the area later took the name Bonnet Carré from the square, right-angle bend of the Mississippi River beside it.

In January 1811, enslaved people rising at Woodland Plantation and neighboring plantations near LaPlace launched the German Coast Uprising, regarded as the largest slave revolt in United States history; it was crushed within three days.

The community is named for Basile Laplace, a pharmacist and planter who arrived in 1879 and in 1883 let the New Orleans and Baton Rouge Railroad cross his plantation; the depot, then the post office, and finally the town took his name.

In 1971 the St. John the Baptist Parish Police Jury decreed that the official spelling of the community's name is 'LaPlace,' with a capital P.

The 2020 census counted 28,841 residents in LaPlace, down slightly from a peak of 29,872 in 2010, making it the largest community in St. John the Baptist Parish, a parish with no incorporated municipalities, whose seat is Edgard.

The 2010 census counted 9,888 housing units in the CDP.

Interstate 55 and U.S. Highway 51 both have their southern termini in LaPlace, at the junction of Interstate 10 and U.S. Highway 61 (Airline Highway), about 25 miles west of New Orleans.

In the 1970s Governor Edwin Edwards proclaimed LaPlace the 'Official Andouille Capital of the World,' and the community has celebrated its smoked sausage with an Andouille Festival each October since 1972.

The Port of South Louisiana is headquartered in LaPlace, and major area employers include Shell Chemical, DuPont, ADM Growmark, and the ArcelorMittal steel plant.