Crime Scene and Trauma Cleanup in Defiance, MO

Defiance is an unincorporated community and census-designated place in St. Charles County, counted by the Census Bureau for the first time in 2020, when it had 159 residents.

The Census Bureau drew an unusually large rural boundary for the Defiance CDP — about 56 square miles of western St. Charles County — so its 159 residents live at a density of under 3 people per square mile.

Defiance was the final home of frontiersman Daniel Boone, who settled in the Femme Osage Valley in 1799 after receiving a Spanish land grant — though the hamlet itself was not named until long after Boone's lifetime.

Daniel Boone died on September 26, 1820, at the Defiance-area home of his youngest son, Nathan Boone; that stone house, the Daniel Boone Home, is now a historic site open for tours.

The Daniel Boone Home, the Daniel Boone Hays House, and the Isaac McCormick House near Defiance are all listed on the National Register of Historic Places.

Defiance got its name in the late 1800s when the Katy Railroad arrived: the settlement was first to be called Parsons after the landowner, but since a Parsons, Kansas already existed on the Katy line, residents chose Defiance to mark their defiance of rival Matson in winning a station on the line.

The Katy Trail State Park — the rail trail built on the old Katy line — runs through Defiance near the Missouri River, making the village a popular trail stop.

Defiance sits at the gateway to Missouri wine country: Highway 94 west from Defiance toward Marthasville is lined with wineries and is sometimes called the Missouri Weinstrasse, in the heart of the Missouri Rhineland.

Defiance was struck hard during the tornado outbreak of December 10–11, 2021, when an EF3 tornado hit the community and one person was killed.

Defiance students are served mostly by the Francis Howell School District, attending Daniel Boone Elementary School in nearby New Melle, Francis Howell Middle School, and Francis Howell High School.