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Manheim is a borough in northern Lancaster County that was named after Mannheim, Germany; its Pennsylvania German name is Mannem.

Manheim was laid out in 1762 by Henry William Stiegel, the colonial glassmaker and ironmaster, and the borough was incorporated in 1838.

Stiegel founded the Manheim Glassworks as part of his planned industrial empire, but financial failure forced him to sell the development in 1775, and the glassworks closed for good in 1780.

The first railroad train arrived in Manheim on January 1, 1862, with the completion of the first division of the Columbia and Reading Railroad.

Manheim's population was 5,046 at the 2020 census, up from 4,858 in 2010 but still below its peak of 5,434 in 1970; the 2000 census counted 1,989 households in the borough.

During the Revolutionary War, Sarah Franklin Bache, the daughter of Benjamin Franklin, took refuge in a home on the northeast corner of Manheim's Market Square while the British occupied Philadelphia.

The Manheim Community Farm Show is held during the first week of October every year at the borough's Memorial Park.

Glassmaking survives in Manheim at Stiegel Glassworks 1976, a working glass studio named for the town's founder where visitors can watch glass being made and create their own pieces.

Manheim is served by the Manheim Central School District and Manheim Central High School.

Chiques Creek, a tributary of the Susquehanna River, forms Manheim's eastern boundary, and Pennsylvania Route 72 runs through the borough as Main Street.