Blood, Trauma, and Biohazard Cleanup in Mayesville, SC

Mayesville is an incorporated town in Sumter County, South Carolina, and is part of the Sumter, South Carolina Metropolitan Statistical Area.

The community grew up around the plantation of Matthew Peterson Mayes, known as "the Squire," who moved to the area from Virginia and purchased a plantation there before 1819.

In 1852 the Wilmington and Manchester Railroad ran its line through the Mayes family's property and built a depot called Mayes Station, replacing the earlier name Bradleyville, and the community became known as Mayesville.

Union soldiers destroyed the railroad through Mayesville during the Civil War, but the town rebuilt and recovered.

The town of Mayesville officially incorporated in 1878.

Mayesville is the birthplace of Mary McLeod Bethune, the famed African American educator.

In 1882 Emma Jane Wilson founded the Mayesville Industrial and Educational Institute in Mayesville to educate African-American children; the school began in a gin house shed and taught trades including shoemaking, carpentry, blacksmithing, sewing, and cooking.

The Mayesville Historic District, which reflects the cultural, commercial, and architectural development of a small 19th-century South Carolina community, is listed on the National Register of Historic Places.

The 2020 United States census counted 548 people in Mayesville, a steep decline from 731 in 2010 and 1,001 in 2000.

Mayesville covers 1.0 square mile, all of it land.