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Moore is an unincorporated community and census-designated place in north central Frio County, Texas, at the intersection of U.S. Highway 81 and Farm Road 462, about thirteen miles northeast of Pearsall, the county seat.

Moore probably takes its name from pioneer R. W. 'Mustang' Moore, who, after an Indian raid in 1861, was found mortally wounded on the front porch of his cabin on Moore Hollow Creek, just west of the present community.

August and Louisa Obets became the first permanent settlers at Moore Hollow in 1874, built the community's first frame house in 1876, and in 1881 fifty acres were sold as a townsite for Moore Hollow.

When the railroad arrived, the settlement became a station called Moore's Station, and by 1884 it was a shipping point for wool with an estimated fifty residents, a hotel, a saloon, and two general stores.

The community's name was shortened in stages, to Moore Station in 1892 and finally to Moore in 1897.

Moore declined during the 1920s and early 1930s as the boll weevil infested the region and ranching replaced dry-land farming, and the Moore school was absorbed by the Pearsall school system in 1950.

The Census Bureau first counted Moore as a census-designated place in 2000, when it recorded 644 residents spread over about 31 square miles; the CDP was later redrawn to roughly 6 square miles.

The 2020 census counted 610 residents in the Moore CDP, up from 475 in 2010.

In the 2000 census about 46 percent of Moore's residents were Hispanic or Latino, and the median household income was $39,063.