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Thompsons is a tiny incorporated town in eastern Fort Bend County, about twelve miles southeast of Richmond on Farm Road 2759, within the Houston metropolitan area.

Settlement around Thompsons began about 1830, when Robert E. Bohannon received a Mexican land grant under Stephen F. Austin's empresario colony; after Bohannon died, his widow married Hiram Thompson, who named the community after himself.

Thompsons became a station on the Gulf, Colorado and Santa Fe Railway in 1879 — it was once called Thompson's Switch — and received a post office in 1888.

By 1896 Thompsons had an estimated 300 residents served by a cotton gin, a general store, and two saloons, but its population fell to about 75 for much of the early 20th century.

In 1903 the Thompsons school district, surrounded by former plantations farmed mostly by Black tenant farmers, operated three Black schools with 175 pupils and one white school with eight pupils.

Thompsons did not incorporate until 1979, when residents elected a mayor and five aldermen and later built a city hall, a park, and a fire department.

The 2020 census counted only 156 residents in Thompsons, down sharply from 246 in 2010.

The 2000 census counted 236 people living in just 93 households in Thompsons, giving the town an unusually small household base.

Although Thompsons spans about 8.3 square miles, more than 40 percent of that area is water, so its settled land amounts to under five square miles.