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Mesquite is a city in the northeast corner of Clark County, Nevada, adjacent to the Arizona state line and 80 miles northeast of Las Vegas on Interstate 15, and it had a population of 20,471 at the 2020 census.

Mesquite was settled by Mormon pioneers in 1880, who called it Mesquite Flat, and the community was finally established on the third attempt after having been flooded out twice by the waters of the Virgin River.

The community was named for the mesquite timber near the original town site, the name was later shortened to Mesquite, and the city was incorporated on May 24, 1984.

Mesquite's population grew from 1,871 in 1990 to 15,276 in 2010 and 20,471 in 2020, and the 2020 census recorded 9,449 households in the city.

The 2020 census put Mesquite's median age at 62.5 years, with 44.5 percent of residents aged 65 or older, and 93.4 percent of residents lived in urban areas.

Mesquite lies in the Virgin River valley adjacent to the Virgin Mountains in the northeastern Mojave Desert, near the southern mouth of the Virgin River Gorge.

Interstate 15 passes through the city, leading southwest 80 miles to downtown Las Vegas and northeast 39 miles to St. George, Utah, and Nevada State Route 170 leads south from the center of town across the Virgin River into Bunkerville.

Mesquite is home to several casinos, including the Virgin River Casino, CasaBlanca, Eureka, and Stateline Casino and Motel, and the city also includes the Rising Star Sports Ranch, a non-gaming hotel and sports facility.

The Virgin Valley Heritage Museum has exhibits about area pioneers and local history, and its museum building, built in 1940, is listed in the National Register of Historic Places.

Mesquite is a destination for year-round golf, with over nine public courses in the warm desert climate, and Mesquite Airport provides facilities for general aviation and skydiving.