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Struthers is a city in eastern Mahoning County, Ohio, along the Mahoning River directly southeast of Youngstown, and its motto is 'The City with Heart in the Heart of It All.'

Struthers began in 1798 when John Struthers of Washington County, Pennsylvania, bought 400 acres of Poland Township land and named it Marbletown; after financial ruin in the War of 1812 era, his son Thomas bought the land back in 1865, brought in industry and railroads, and the town took the family name by popular vote.

Struthers sits at the cradle of the Mahoning Valley steel industry: the Hopewell Furnace was built on Yellow Creek in 1803 by Daniel Eaton, and it is mentioned in the first line of Bruce Springsteen's 1995 song 'Youngstown.'

Struthers became an iron producer again with the Anna Furnace in 1869, followed by a sheet mill in 1880 and the J. A. and D. P. Cooper Gear Company plant in 1888.

Struthers was incorporated as a village in 1902 and grew so fast on steel jobs that it became a city in 1920, drawing waves of European immigrants; its population peaked at 15,631 in 1960.

Struthers flourished until 1977, when several Mahoning Valley steel plants closed for good, and its population has declined steadily since, reaching 10,063 at the 2020 census.

Struthers gave its name to a landmark First Amendment case, Martin v. Struthers, in which the U.S. Supreme Court struck down the city's fine on a Jehovah's Witness who distributed religious pamphlets door-to-door in 1943.

The 2020 census counted 4,336 households in Struthers, and the city's heritage is heavily European: in 2010, residents reported Italian (28.4%), German (25.0%), Irish (20.0%), and Slovak (13.2%) as their leading ancestries.

Struthers' Nebo neighborhood, on the city's east side, historically contained a significant Slavic American population.

Students in Struthers attend Struthers High School, which also hosts WKTL 90.7 FM, a local radio station based in the Struthers Fieldhouse.