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Concepcion is an unincorporated community and census-designated place (CDP) in southeastern Duval County, located on Farm Road 716 along Macho Creek, about fourteen miles southeast of Benavides.

Concepcion is one of the oldest towns in Duval County and took its name from the Santa Cruz de Concepción, according to the Handbook of Texas.

Concepcion was thriving in the 1880s — by 1884 it had about 600 residents and three general stores, and local sheep rancher Don Julian Palacios served as justice of the peace.

Concepcion's own school reported 64 pupils enrolled in the 1906–07 school year, and the school eventually merged with the Benavides schools.

Concepcion's population was estimated at 150 in 1914, and from the mid-1930s through the mid-1960s it was usually reported at about seventy-five residents.

Concepcion was first counted as a CDP in the 2000 census; it recorded 62 residents in 2010 and 42 in the 2020 census.

Despite its tiny population, Concepcion is remarkably compact — its roughly 42 residents live within about a tenth of a square mile, a density of more than 500 people per square mile.