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Iago is a census-designated place in southeastern Wharton County, Texas, at the intersection of Farm Roads 1301 and 1096, two miles northwest of Boling and twelve miles east of Wharton.

Iago's name is pronounced 'Eye-a-go,' and locals render it phonetically to distinguish it from the Shakespeare character.

Iago's first school was organized in 1902, and by 1920 the farming community had two cotton gins, a syrup mill, a blacksmith, several stores, a drugstore and doctor, a barbershop, saloons, a church, and a population of 200.

Iago's population reached 300 in 1958 but dropped to 150 by 1964 and to just 56 by 1990, reflecting the decline of the local farm economy.

Iago's school became part of the Boling school district in 1941 and later served as a Boling junior high; today Iago is in the Boling Independent School District, whose high school is Boling High School.

Iago became a separate census-designated place in the 2010 census, when the old Boling-Iago CDP was split into the new Boling and Iago CDPs; Iago counted 161 residents in 2010.

The 2020 census counted 148 people in Iago, spread over a land area of about 1.89 square miles of Gulf Coast plain.